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| On the relationship between fractal geometry of space and time in which a systemof interacting cells exists and dynamics of gene expression. J Konarski, M Molski, P Waliszewski Acta Biochim Polon 2002; 48(1):209-220 ICID: 146515 |
| IC™ Value: 6.80 |
| We report that both space and time, in which a system of interacting cellsexists, possess fractal structure. Each single cell of the system can restore the hierarchical organizationand dynamic features of the entire tumor. There is a relationship between dynamics of gene expressionand connectivity (i.e., interconnectedness which denotes the existence of complex, dynamic relationshipsin a population of cells leading to the emergence of global features in the system that would never appearin a single cell existing out of the system). Fractal structure emerges owing to non-bijectivity of dynamiccellular network of genes and their regulatory elements. It disappears during tumor progression. Thislatter state is characterized by damped dynamics of gene expression, loss of connectivity, loss of collectivity(i.e., capability of the interconnected cells to interact in a common mode), and metastatic phenotype.Fractal structure of both space and time is necessary for a cellular system to self-organize. Our findingsindicate that results of molecular studies on gene expression should be interpreted in terms of space-timegeometry of the cellular system. In particular, the dynamics of gene expression in cancer cells existingin a malignant tumor is not identical with the dynamics of gene expression in the same cells culturedin the monolayer system. |
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ICID 146515 PMID 11440171 - click here to show this article in PubMed database |
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