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| Uncoupling proteins in mitochondria of plants and some microorganisms. W Jarmuszkiewicz Acta Biochim Polon 2002; 48(1):145-155 ICID: 146522 |
| IC™ Value: 6.80 |
| Uncoupling proteins, members of the mitochondrial carrier family, are presentin mitochondrial inner membrane and mediate free fatty acid-activated, purine-nucleotide-inhibited H+re-uptake. Since 1995, it has been shown that the uncoupling protein is present in many higher plantsand some microorganisms like non-photosynthetic amoeboid protozoon, Acanthamoeba castellanii and non-fermentativeyeast Candida parapsilosis. In mitochondria of these organisms, uncoupling protein activity is revealednot only by stimulation of state 4 respiration by free fatty acids accompanied by decrease in membranepotential (these effects being partially released by ATP and GTP) but mainly by lowering ADP/O ratioduring state 3 respiration. Plant and microorganism uncoupling proteins are able to divert very efficientlyenergy from oxidative phosphorylation, competing for deltamicroH+ with ATP synthase. Functional connectionand physiological role of uncoupling protein and alternative oxidase, two main energy-dissipating systemsin plant-type mitochondria, are discussed. |
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ICID 146522 PMID 11440164 - click here to show this article in PubMed database |
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