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| Az endothelin-1 és szerepe diabetes mellitusban. [ [Endothelin-1 and its role in diabetes mellitus] ] B Sármán, M Tóth, A Somogyi Orv Hetil 1998; 138(45):2877-2881 ICID: 153929 | ||
| IC™ Value: 5.00 | ||
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English: Endothelin-1 is mainly synthesised by the vascular endothelial cells and acts on the vascular smooth muscle. There are special endothelin receptors, endothelin receptor-A and endothelin receptor-B expressed on the vascular smooth muscle cells. Endothelin-1 through second messengers mobilises the intracellular calcium storage. The level of endothein-1 was found to be higher than normal in several diseases. Because of its vasoconstrictor and mitogenic effects it plays a role in the development of vascular diseases. The most severe and most frequent complications of diabetes mellitus are micro- and macroangiopathy. The authors summarise the physiological functions of endothelin-1 and its role in the development of diabetic angiopathy. | ||
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ICID 153929 PMID 9432637 - click here to show this article in PubMed database | ||
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