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| Renal hypertrophy in streptozotocin-diabetic rats. L Hársing, I Boros, E Pósch Acta Physiol Hung 1994; 82(1):23-28 ICID: 167251 |
| IC™ Value: 5.00 |
| In male adolescent rats kidney mass attained maximum terminal value alreadyat week 1 after streptozotocin treatment, and this value did not change over the next two weeks. At week1 the kidney size of diabetic rats was greater than that of untreated controls, whereas at week 3 renalmass was the same in both groups. In adult rats with final body and kidney mass streptozotocin treatmentfailed to induce further increment in renal growth, and the kidney size of diabetic animals was the sameas the final kidney size of age-matched control animals. The identity of terminal maximum values forkidney mass in male rats suggests rather an accelerated kidney growth than a true hypertrophic responsein diabetes. Similar conclusion can be drawn from our observations made on the compensatory growth ofthe solitary kidney in diabetic rats with prior uninephrectomy. |
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ICID 167251 PMID 7976392 - click here to show this article in PubMed database |
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