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| Nociceptor functions in intact skin and in neurogenic or non-neurogenic inflammation. L Kocher, P W Reeh, F Anton, H O Handwerker Acta Physiol Hung 1987; 69(3-4):333-342 ICID: 167923 |
| IC™ Value: 5.00 |
| Acute neurogenic or non-neurogenic inflammation was elicited in skin patchesinnervated by the saphenous nerve of anaesthetized Sprague Dawley rats. Lambda carrageenan was used toinduce non-neurogenic inflammation, mustard oil (allyl-iso-thio-cyanate) or antidromic nerve stimulationto induce neurogenic inflammation. Antidromic nerve stimulation yielded plasma extravasation but no significantsensitization of unmyelinated nociceptor units. In contrast, mustard oil and carrageenan yielded plasmaextravasation and sensitization of nociceptors, though carrageenan sensitized only part of them. Sensitizationresulted in ongoing spike discharges and in a shift of response curves to lower temperatures when controlledradiant heat stimuli were applied to the receptive fields. Responses to mechanical stimuli with v. FREYhairs were not significantly altered. Effects of neurogenic and non-neurogenic inflammation on unmyelinatednociceptor units are compared. |
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ICID 167923 PMID 3661217 - click here to show this article in PubMed database |
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