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IndexCopernicus Journal Abstract
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The morphological consequences of neonatal treatment with capsaicin on primaryafferent neurones in adult rats. S N Lawson Acta Physiol Hung 1987; 69(3-4):315-321 ICID: 167977 |
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| Article type: Review article | ||
| IC™ Value: 5.20 | ||
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| A comparison was made using our work and that reported in the literatureof the losses of myelinated and unmyelinated fibres in a variety of nerves and also of losses of nervecells in dorsal root ganglia, after treatment of neonatal rats with capsaicin. In L3 and L4 dorsal roots85-93% of unmyelinated fibres and 9-33% of myelinated fibres were lost after 50-100 mg/kg capsaicin neonatally.In rats treated with 85 mg/kg capsaicin, percentage losses of unmyelinated (89%) and myelinated (36%)fibres of L4 dorsal roots were remarkably similar to the calculated losses of small dark (92%) and largelight (34%) neurones respectively in these ganglia. Studies with monoclonal antibody RT97 which labelsthe large light neurones only, confirmed that some RT97 negative cells (i.e. small dark neurones) remainafter capsaicin treatment. At present no evidence exists to suggest that the cell death of small darkneurones or C fibres after neonatal capsaicin treatment is completely selective for subgroups of theseneurones, either in relation to sensory modality, or in relation to immunocytochemical cell markers andpeptide content. However much more data is required to establish whether this cell death is really nonselectiveas regards immunocytochemical markers. | ||
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ICID 167977 PMID 3310521 - click here to show this article in PubMed database |
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