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| Effect of a substance P antagonist on capsaicin-induced nociceptive reflexin the isolated spinal cord-tail preparation of the rat. M Yanagisawa, M Otsuka Acta Physiol Hung 1987; 69(3-4):363-366 ICID: 168010 |
| IC™ Value: 5.00 |
| An isolated spinal cord-tail preparation of the newborn rat was developedand used for studying the effects of various drugs. The cord and the tail were separately perfused withoxygenated artificial cerebrospinal fluid. Application of capsaicin in a small amount to the tail induceda depolarizing response of the lumbar ventral root (L3-L5) lasting for about 30 sec. The stimulatingaction of capsaicin was potentiated by previous perfusion of the tail with a medium containing prostaglandinE1 or E2. The capsaicin-induced nociceptive reflex was depressed by application to the spinal cord ofmorphine, Met-enkephalin, dynorphin (1-13), somatostatin, adenosine, GABA and a substance P (SP) antagonist[D-Arg1, D-Pro2, D-Trp7,9, Leu11]SP, and potentiated by bicuculline. The present preparation will beuseful for the future studies on pain and analgesic drugs. |
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ICID 168010 PMID 2444068 - click here to show this article in PubMed database |
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