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| Pharmacological characterization of postsynaptic potentials evoked in the bimodalpacemaker neuron of Helix pomatia L. A Vehovszky, J Salánki Acta Physiol Hung 1983; 62(1):35-46 ICID: 168262 |
| IC™ Value: 5.00 |
| Stimulation of various peripheral nerve trunks evokes very similar compoundpostsynaptic potentials (PSP) composed of one or more excitatory postsynaptic potentials (EPSP) followedby fast and slow inhibitory postsynaptic potentials (IPSP) on the identified RPal neuron of Helix pomatiaL. Evoked EPSPs were reduced or blocked by nicotine, atropine and d-tubocurarine. The two componentsof IPSP were different in their pharmacological sensitivity. Slow IPSP was partly or totally eliminatedby ergometrine and chlorpromazine and was reduced by atropine, nicotine as well as by propranolol. FastIPSP was reduced only in the presence of ergometrine and could not be blocked by either of the applieddrugs. Participation of cholinergic transmission seems to be essential in the evoked EPSP but its partialinvolvement in the slow IPSP can also be supposed. A dopaminergic mechanism may take part in the generationof both components of IPSP but the receptors responsible for the slow IPSP were sensitive to other catecholamineantagonists as well, referring to a more complex origin, or to the involvement of an unknown transmitter.Comparison of PSPs evoked by stimulation of different nerves shows that presynaptic areas belonging tovarious peripheral sources are overlapped on the RPal neuron, and they probably act by similar transmittersubstances. |
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ICID 168262 PMID 6650194 - click here to show this article in PubMed database |
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