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| Hypothalamic nitric oxide synthase activity during sexual maturation in femalerats. Effects of estrogens. Roxana Reynoso, Claudia Mohn, Berta Szwarcfarb, Osvaldo Ponzo, Silvia Carbone, Pablo Scacchi, Jaime A Moguilevsky Neuroendocrinol Lett 2004; 25(3):219-222 ICID: 400960 |
| IC™ Value: 12.86 |
| OBJECTIVES: To determine the hypothalamic activity of nitric oxide synthase(NOS, the enzyme involved in the synthesis of nitric oxide NO) during sexual maturation in prepubertal(15 days old) and peripubertal female rats (30 days old) as well as the effect of estradiol administrationon this neurotransmitter system. METHODS: Hypothalamic samples containing the anterior preoptic and medialbasal areas (APOA-MBH) were homogenized with HEPES 20 mM, pH = 7.4 and NOS activity was determined inAPO-MBH after 10 minutes of incubation by the conversion of 14C arginine to 14C citrulline. RESULTS:The hypothalamic concentration of NOS is significantly higher in peripubertal than in prepubertal rats.Treatment with EB increased significantly the activity of the enzyme in both groups compared with controland the increases was similar at both ages. CONCLUSIONS: These results clearly demonstrated that thehypothalamic NOS activity increases in peripubertal rats as compared with prepubertal animals. Estradiolhas a similar stimulatory effect on hypothalamic NOS activity at both ages of sexual maturation, indicatingthat the increase in NOS during sexual maturation is connected with the peripubertal increase of estradiolrather than an increase in the sensitivity of the enzyme to the ovarian hormone. |
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ICID 400960 PMID 15349089 - click here to show this article in PubMed database |
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