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IndexCopernicus Journal Abstract
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Serum testosterone and corticosterone levels in acute experimental autoimmuneencephalomyelitis (EAE) in male Wistar rats. Daniela R Macció, Gastón Calfa, Marta Volosín, German A Roth Neuroendocrinol Lett 2004; 25(3):196-200 ICID: 400964 |
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| IC™ Value: 12.86 | ||
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| OBJECTIVES: Experimental autoimmune encephalomyelitis (EAE) was inducedto investigate the levels of circulating total testosterone (TT) and the possible association of corticosteronewith the steroid-producing capacity of the testes. SETTING AND DESIGN: We determined gonad weights, serumTT and corticosterone levels during the development of EAE in male rats. METHODS: Active EAE was inducedin young male Wistar rats by injection of whole myelin in complete Freund's adjuvant. All the rats wereweighted and monitored daily for clinical signs and blooded during different phases of the disease. SerumTT was measured by radioimmunoassay and circulating corticosterone was determined using a competitiveenzyme immunoassay. Also testes and seminal vesicles were removed to determine their weights. RESULTS:Seminal vesicle weights and serum TT levels diminished during the acute stage of the disease in all EAErats and then they began gradually to increase, reaching the normal values at the post-recovery phase.Concomitantly a significant increase in serum corticosterone levels was observed during the acute EAEand the post-recovery phase was accompanied by a decline in corticosterone levels. MAIN FINDING: Ourresults indicated an inverse correlation between serum TT and corticosterone levels during the acuteEAE. Moreover, the diminution of TT was not a consequence of an alteration of the testes induced by anti-myelinantibodies neither contributed by apoptosis of testis cells by exposure to corticosterone. CONCLUSIONS:The negative correlation between corticosterone and TT levels associated to EAE may be relevant in understandingthe association of the endocrine system and the development of autoimmune demyelinating diseases. | ||
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ICID 400964 PMID 15349085 - click here to show this article in PubMed database |
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