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| Leptin gene expression in the hypothalamus and pituitary of pregnant pigs. Nina Smolinska, Jadwiga Przala, Tadeusz Kaminski, Gabriela Siawrys, Alina Gajewska, Kazimierz Kochman, Stanislaw Okrasa Neuroendocrinol Lett 2004; 25(3):191-195 ICID: 400965 |
| IC™ Value: 12.86 |
| BACKGROUND: Leptin, the 16-kDa peptide hormone product of the ob gene,is a regulatory hormone secreted mainly by adipose tissue. Recent studies have shown leptin productionby other tissues, including rat hypothalamus, rat and human pituitary, rat skeletal muscle, kidney andstomach, human and porcine placenta, human mammary epithelial cells as well as endometrial tissues. Thishormone is a central modulator of food intake, metabolism and neuroendocrine functions. OBJECTIVES: Theaim of the study was to detect and locate porcine leptin gene expression in the different areas of thehypothalamus and pituitary on days 14-16 and 30-32 of pregnancy in pigs. METHOD: Leptin gene expressionwas analysed by RT-PCR method. PCR products were subjected to sequencing analysis. RESULTS: Leptin mRNAwas expressed in the medial basal hypothalamus, preoptic area, stalk median eminence, anterior pituitary,posterior pituitary and adipose tissue on days 14-16 and 30-32 of pregnancy. Sequence analysis of the258 bp product from the hypothalamus and pituitary confirmed 99% homology with the corresponding regionof porcine leptin cDNA sequence. CONCLUSION: Leptin mRNA expression in the porcine hypothalamus and pituitarygland implies its paracrine and/or autocrine role in the regulation of hypothalamic-pituitary axis activity. |
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ICID 400965 PMID 15349084 - click here to show this article in PubMed database |
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