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| Responsiveness of microcirculation and local cold vasodilation to capsaicinin the intact and chronically denervated canine tongue. K Pleschka, K Diebold, R Hardt, J U Meyer Acta Physiol Hung 1987; 69(3-4):367-373 ICID: 401293 |
| IC™ Value: 5.00 |
| Lingual blood flow and its distribution were determined at rest and inresponse to local cooling of the tongue (32 degrees C) in 6 anaesthetized, paralyzed and artificiallyventilated dogs before and after two intraarterial (i.a.) injections of capsaicin (2.5 mg) at an intervalof about 40 min. In 3 dogs, the same protocol was performed after degeneration of the chorda-lingualand glossopharyngeal nerves due to prior transection. In general the first i.a. injection of capsaicinresulted in a marked and the second injection in a smaller decrease of lingual blood flow. Local coolingof the tongue induced significant increases in lingual blood flow before as well as after capsaicin treatment,regardless of whether sensory innervation was intact or degenerated. In both the untreated and capsaicintreated dogs the increase in lingual blood flow during local cooling of the tongue was solely due toan increase in blood flow through the arteriovenous anastomoses, while blood flow through the capillariesof the mucosa and muscles even decreased. The findings suggest that capsaicin-induced vasoconstrictionof the tongue vessels is due to a direct effect on vascular receptors. It is further suggested that coldvasodilatation of the canine tongue is not mediated by axon collaterals releasing substance P. Directthermal effects on the intramural ganglia and the postganglionic vasomotor efferents innervating theAVAs, or on AVAs basal tone itself are suggested as the underlying mechanism. |
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ICID 401293 PMID 3661218 - click here to show this article in PubMed database |
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