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| EFFeCTS OF CASSIA PODOCARPA LEAVES EXTRACTS ON THE RAT ILEUM AND COLON (IN VITRO) R AKOMOLAFE, I ADEOSHUN, A ELUJOBA, E IWALEWA4, A AYOKA Bol Latinoam Caribe Plant Med Aromaticas 2004; 3(3):52-57 ICID: 842715 | ||
| Article type: Original article | ||
| IC™ Value: 3.00 | ||
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| Ethnopharmacology and scientific reports indicate the use of C. podocarpa leaf as a purgative recipe. This study attempts to find the in vitro effects of its aqueous infusion (ACPL) and methanolic extract (MCPL) on the intestines of rats, using those of C. acutifolia leaf (ACAL and MCAL) as reference standard. MCPL relaxed the ileum and colon dose dependently. Its effect was blocked by tolazoline. ACPL and ACAL contracted the colon dose dependently. Hexamethonium potentiated the effect of ACPL, while nifedipine blocked it. MCAL relaxed the ileum dose dependently. Its effect was blocked by olazoline. The effect of ACAL was blocked by atropine, promethazine and nifedipine. ACPL was more potent than ACAL in contracting the colon. These results then suggest the following: MCPL and MCAL relaxed the ileum by a–adrenergic system. ACPL caused purgation by L-type calcium channel activation. ACAL caused purgation by cholinergic system, H1 receptor stimulation and calcium channel activation. Hexamethonium potentiation of ACPL action on the colon could be due to allosteric activation of the muscarinic receptors | ||
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ICID 842715 | ||
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