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| SCREENING OF CLONIDINE EFFECT ON BRAIN ACETYLCHOLINE CONTENT, ANTICONVULSANT AND LOCAL ANAESTHETIC PROPERTIES [ SCREENING OF CLONIDINE EFFECT ON BRAIN ACETYLCHOLINE CONTENT, ANTICONVULSANT AND LOCAL ANAESTHETIC PROPERTIES ] KHUWAJA AHMAD, JAMES CROSSL, VINAK KRISHAN I.N, EL. AKKAD Pak. Jour. of Pharm. Sci 1988; 1(1):11-17 ICID: 901142 |
| Article type: Original article |
| IC™ Value: 3.00 |
| Clonidine, a potent centrally acting antihypertensive drug was screened for effect on ‘free” and “bound” acetylcholine (Ach) in brain of morphine dependent and morphine withdrawal rats, anticonvulsant activity and morphine withdrawal rats, anticonvulsant activity and local anaesthetic activity. “Free” and “total” Ach content in normal (non-dependent) animals as well as in animals dependent to morphine was not changed by clonidine. Naloxone produced abstinence syndrome in dependant rats with highly significant increase in “free” Ach. Clonidine pretreatment decreased the rise of “free” Ach content produced by naloxone. It failed to show any anticonvulsant effect against maximal electroshock convulsions in rats, however, it exhibited significant local anaesthetic activity. Diuresis, piloerection and convulsions were observed with higher doses of clonidine. |
: Clonidine, a potent centrally acting antihypertensive drug was screened for effect on ‘free” and “bound” acetylcholine (Ach) in brain of morphine dependent and morphine withdrawal rats, anticonvulsant activity and morphine withdrawal rats, anticonvulsant activity and local anaesthetic activity. “Free” and “total” Ach content in normal (non-dependent) animals as well as in animals dependent to morphine was not changed by clonidine. Naloxone produced abstinence syndrome in dependant rats with highly significant increase in “free” Ach. Clonidine pretreatment decreased the rise of “free” Ach content produced by naloxone. It failed to show any anticonvulsant effect against maximal electroshock convulsions in rats, however, it exhibited significant local anaesthetic activity. Diuresis, piloerection and convulsions were observed with higher doses of clonidine. |
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ICID 901142 |
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