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| Apolipoprotein E epsilon 4 allele frequency is not increased in progressive supranuclear palsy. M Tabaton, M Rolleri, P Masturzo, S Cammarata, G Angelini, L A Hansen, T Saitoh, R B Petersen, G Perry, P Richey Neurology 1995; 45(9):1764-1765 ICID: 907885 |
| Article type: Original article |
| IC™ Value: 10.00 |
| We examined apolipoprotein E (ApoE) immunoreactivity and allele frequency in 12 autopsied cases of progressive supranuclear palsy (PSP), a neurodegenerative disease characterized by diffuse neurofibrillary tangle (NFT) formation without beta-amyloid deposits. In spite of the ApoE immunoreactivity associated with NFTs, in PSP the ApoE allele frequency was comparable with that of age-matched normal controls. This suggests that in Alzheimer's disease the increased frequency of ApoE epsilon 4 does not influence neurofibrillary degeneration, but is probably linked to beta-amyloid deposition. |
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ICID 907885 PMID 7675243 - click here to show this article in PubMed database |
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